“Comparative Evaluation of Oral Midazolam, Oral Ketamine And Oral Midazolam-Ketamine Combination As Conscious Sedative Agents in Uncooperative Pediatric Dental Patients”

Conscious Sedation is a technique in which the use of a drug produces a state of depression of central nervous system enabling treatment to be carried out, but during which verbal contact with the patients is maintained throughout the period of sedation. Various drugs have been used as sedative agents in pediatric dentistry to produce conscious sedation such a nitrous oxide, diazepam, midazolam, propofol, Ketamine, temazepam, chloral hydrate, hydroxyzine hydrochloride, promethazine. The aim of the research is to record the onset of action, any changes in the vital parameters, body movements, sleep and crying and compare between the following: a) Oral midazolam (M) b)Oral Ketamine (K) c)Oral midazolam-oral Ketamine combination (MK) and also to note down the behavioral outcome of uncooperative pediatric dental patients following the administration of oral midazolam, oral Ketamine and oral midazolamKetamine combination as conscious sedation agents as per: sleep, Bodily movement, crying. Study also observes any adverse reactions following the administration of drug during the duration of recovery. Statistical tools are used for study. Results show that Ketamine is a better anxiolytic agent followed by midazolam then midazolam-Ketamine combination. Although midazolam-Ketamine combination was not a good agent for conscious sedation it could counteract the side effects of Ketamine .Thus, we can conclude that the combination could be used in smaller doses for conscious sedation while taking safety into consideration.